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Mutations at the helix 23 and helix 14 FAT-paxillin binding sites inhibit FAK localization, FAK and paxillin phosphorylation, focal adhesion turnover, cell adhesion, migration, and invasion 25,26,28

Refrigeration or freezing of the lyophilized material is recommended for extended stability, according to laboratory SOPs

This bidirectional regulation suggests sophisticated sensing of tissue microenvironmental cues, enabling GHK-Cu to normalize MMP activity toward homeostatic levels rather than exerting uniform stimulatory or inhibitory effects

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Chromatographic separation was performed with an Agilent InfinityLab Poroshell 120 HILIC-Z (2.1 100 mm, 2.7 m (p/n 675775-924)) column