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173 At the molecular level, gene modulation techniques, including siRNA- and shRNA-mediated silencing of efflux transporter genes (e.g., ABCB1, ABCG2), as well as CRISPR/Cas9-based gene editing, have successfully resensitized tumor cells to chemotherapy in preclinical models
Mitochondrial Fe 2+ generally severs three functions, including synthesis of heme and Fe-S clusters or storage in mitochondrial FT
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Upon sufficient apoptotic stress, BH3-only proteins neutralize anti-apoptotic BCL-2 family members and/or directly activate BAX and BAK
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