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Proven track record: The injectable form has been the primary standard for significant weight loss results in clinical settings

In the trial, for patients with preexisting cardiovascular disease and overweight or obesity but without diabetes, weekly injections of semaglutide at a dose of 2.4 mg was superior to placebo in reducing the risk of death from cardiovascular causes, nonfatal heart attack, or nonfatal stroke over an average follow-up of 40 months

RNA binding by ASOs can promote degradation of the bound RNA molecule, modulate the processing of the RNA through splicing and polyadenylation, or otherwise affect the translation of mRNA into protein, such as by disrupting RNA structures that block translation (Bennett et al., 2019

Patients should plan for the program to end on December 31, 2027 unless extended

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