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[Ref] Cardiovascular Very common (10% or more): Increased heart rate Common (1% to 10%): Hypotension Uncommon (0.1% to 1%): Orthostatic hypotension Increased heart rate was reported with a mean increase of 1 to 4 beats per minute (bpm) across trials, with maximum changes of 10 to 19 bpm in up to 41% of treated adult patients vs 34% placebo, and 20 bpm or more in up to 26% vs 16% placebo
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In some cases, you may feel numbing of toes or fingers
For example: The STEP 1 trial, published in The New England Journal of Medicine in 2021, found that semaglutide led to significant weight loss and improvements in metabolic markers, with secondary data suggesting modest reductions in lean mass
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