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The 2023 Endocrine Society Clinical Practice Guideline on Obesity in Adults recommends that clinicians counsel all patients of reproductive age about the need for effective contraception during GLP-1 therapy and a minimum 2-month pre-conception washout period [8]
[1] The authors reported that methylquinolinium analogs with primary-amine substitutions displayed high permeability from passive and active transport across membranes, measured using two standard in-vitro models: the parallel artificial membrane permeability assay (PAMPA) and Caco-2 human intestinal cell monolayers
These effects are temporary, however
All cages were kept in the same row of each rack
