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Nevertheless, for this reason alone, current evidence is not confirmatory
The determining factor is not the medication itself, but how well the underlying physiology is supported
If youre already taking compounded semaglutide, its important to talk to your healthcare provider as soon as possible to understand your options moving forward
Abbreviations BMP: bone morphogenetic protein CMap: Connectivity Map COPD: chronic obstructive pulmonary disease CT: computed tomography DLCO: diffusing capacity of carbon monoxide DMEM: Dulbecco's modified Eagle's medium ECM: extracellular matrix FBS: fetal bovine serum FDR: false discovery rate FEV 1 : forced expiratory volume in 1 second FVC: forced vital capacity GOLD: Global Initiative for Chronic Obstructive Lung Disease GSEA: Gene Set Enrichment Analysis Lm: mean linear intercept PBS: phosphate-buffered saline TGF: transforming growth factor Vv: volume fraction
A separate Phase 2 trial in people with type 2 diabetes was also published in the NEJM in 2023, reporting meaningful reductions in HbA1c alongside weight loss
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