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Long-term human safety outcomes involving endocrine, cardiovascular, or oncologic risk remain poorly characterized, and BPC-157 should continue to be framed as investigational rather than established therapy [1]
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They are highly toxic to the liver and are amongst the major identified risk factors for hepatocellular carcinoma 10,11,12
studied mutant mice lacking MC1R (termed Mc1r e/e ) and found an influence as expected, but surprisingly this was an increased tolerance, not sensitivity, to thermal and inflammatory (formalin-induced) pain (but not neuropathic pain following peripheral nerve injury) which was confined to females
10.1016/S0891-5849(99)00275-0 Free Radic Biol Med
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