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To investigate the role of ghrelin for the regulation of postprandial GLP-1 by TMPRSS2, we inhibited ghrelin signaling with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 (47) before refeeding

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To dissect the role of caspases in the observed profile, we included two inhibitors: Q-VD-OPh (referred to hereafter as QVD), a pan-caspase inhibitor targeting caspases 1, 3, 7, 8, 9, 10 and 12, and Ac-DEVD-CHO (referred to hereafter as DEVD), which selectively inhibits caspases 3, 6, 7, 8 and 10

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