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Healthy mitochondria are essential for neuronal health and function
However, the story is nuancedthe failure of the EVOKE trials testing oral Semaglutide in symptomatic Alzheimers Disease does not invalidate the strong epidemiological signal for GLP-1 agonists in dementia prevention, and SS-31s approval establishes important regulatory precedent for mitochondrial-targeted therapeutics
The tables below cover injectable protocols from 1mg to 3mg daily, topical applications from 0.5% to 4% concentration, and reconstitution calculations for both 50mg and 100mg vials
doi: 10.1073/pnas.1821323116 26 LinT
(2020) 69:e12667
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