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Similarly, in a separate study of individuals with biopsy-confirmed non-alcoholic steatohepatitis (NASH), EAA measured by the Horvath clock correlated with hepatic collagen content, though not fibrosis stage, and revealed differentially methylated CpG sites enriched in developmental and transcriptional regulatory pathways 16

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For example, enteric neurons express glutamate transporters and are in close proximity to VANs expressing glutamate-sensitive receptors 75

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