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How do GLP1 medications work

The consensus, if one exists, is this: split dosing is a pharmacologically reasonable modification that has not been clinically validated

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10.1056/NEJMoa1901118 27 HutubessyR.ChisholmD.EdejerT

Practical Protein Strategy When Using Retatrutide For individuals using retatrutide or GLP-1 medications, a simple nutritional approach is: Prioritize protein first at every meal Build meals around lean protein sources Add carbohydrates and fats after protein needs are met Most clinical nutrition guidelines for fat loss recommend protein intake in the range of: 1.62.2 grams of protein per kilogram of body weight per day Maintaining adequate protein intake ensures that the metabolic benefits of retatrutide and GLP-1 therapies translate into fat loss rather than unnecessary muscle loss, helping preserve long-term metabolic health and body composition