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HO-1 attenuates the generation of oxidants by diabetes and uncouples nitric oxide synthase (NOS) to mediate the inhibition of PKC and NADPH oxidase in the endothelial cell (43, 46)
Results vary based on: Starting weight Metabolic factors Consistency with treatment Most are mild and temporary: Nausea (usually subsides in weeks) Constipation Headaches Severe side effects are rare but include pancreatitis or gallbladder issues
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