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Donnelly JE, et al
Gastrointestinal side effects such as nausea and vomiting typically start within the first few days to weeks after beginning treatment or after increasing the dose but tend to improve over time
at 10 nmol/kg/d: mean difference 34.6%, 95% CI 13.0% to 56.1%, p = 0.0015)
10.1046/j.1365-201X.1997.00161.x 218
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