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The dosage and frequency depend on the severity of the deficiency and the underlying cause
Systemically, because it involves copper, there is a theoretical risk of copper overload with prolonged, high-dose use without proper cycling
Early warning signs of hypoglycemia may be less obvious in patients with hypoglycemia unawareness which can be due to a long history of diabetes (where deficiencies in the release or response to counter regulatory hormones exist), with autonomic neuropathy, intensified diabetes control, or taking beta-blockers, guanethidine, or reserpine
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