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Most (70% to 80%) lost 5% or more of their body weight

Author contributions AFW: Conceptualization, Methodology, Software, Formal Analysis, Investigation, Visualization, Data curation, Writing original draft, Writing review and editing

was supported by a Wellcome Trust Senior Investigator Award (WT098424AIA), MRC Program grants (MR/J0003042/1, MR/L020149/1) and Experimental Challenge Grant (DIVA, MR/L02036X/1), BBSRC (BB/J015873/1), MRC (MR/N00275X/1), Diabetes UK (BDA/11/0004210, BDA/15/0005275, BDA 16/0005485) and Imperial Confidence in Concept (ICiC) grants, and a Royal Society Wolfson Research Merit Award

Oxidative stress and inflammation are inextricably related, jointly causing and exacerbating the effects of the other ( Our previously single-center clinical studies indicated CHF might have nephroprotection in A on C patients ( Ligusticum wallichii (Chuanxiong) , has the potential to prevent AKI via a variety of processes, including ameliorating oxidative stress damage, suppressing inflammatory responses, deterring apoptotic cell death of intrinsic renal cells, and modulating autophagy ( Renal fibrosis is by far the most important mechanism that leads to CKD ( 1 is the primary profibrotic facilitator in kidney disorders due to its role as a key modulator of fibrosis ( 1 have additionally validated the profibrotic function of TGF- 1 in the etiology of progressive renal fibrosis in a variety of kidney illnesses (Wong et al., 2017