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The overall safety profile of sermorelin in published literature is favorable, reflecting its physiological mechanism of action

Unlike in adults, children and adolescents need energy and sufficient calories not only for physical activity, but for growth and development." The balance of energy intake (diet) and energy expenditure (such as physical play and exercise) influences a childs growth and health across their lifespan, and any change in the balance of these two factors can adversely impact health much later in life

& Thyssen, J

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In skeletal muscle, they downregulate atrophy-associated genes (MuRF1, MAFbx) and upregulate myogenic factors (MyoD, MyoG), thereby improving perfusion and energy metabolism