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Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology Importantly, imaging and metabolic studies consistently show that reductions in cerebral glucose metabolism and perfusion precede cognitive symptoms by years, often decades [8]

Allodynia is pain caused by stimuli that do not normally cause pain, such as light touch or normal clothing contact

Yamaji, T., Teranishi, T., Alphey, M.S., Crocker, P.R

The secondary objectives were to compare the changes in HbA1c between Met+Sita and Sita+Acarb group, and to evaluate the changes in body weight, waist circumference, systolic and diastolic blood pressures, fasting and postprandial 2-hour glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) in three groups

Biol Plant 52:561564 Singh H, Kumar D, Soni V (2020) Copper and mercury induced oxidative stresses and antioxidant responses of Spirodela polyrhiza (L.) Schleid