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In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

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Advanced (Weeks 9-12) Dose : 500 mcg subQ (split 250 mcg AM/PM) Frequency : Twice daily Duration : 8-12 weeks, monitored For metabolic resistance