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DSIP Timeline & What to Monitor Older trials measured sleep architecture changes within the first or second night of dosing, using polysomnography
The elements that belong on it are HPLC purity with ultraviolet detection at a wavelength appropriate to the quinolinium chromophore, identity confirmed by nuclear magnetic resonance and by mass spectrometry, an explicit statement of the salt form and counterion, residual solvent content from the synthesis, and water content
The first study I could find using DSIP for treating withdrawal symptoms was published in 1983: DSIP (25 nmol/kg) was injected intravenously as sole treatment to 67 patients presenting withdrawal symptoms (28 from ethyl alcohol, 39 from opiates)
The FDA flagged theoretical immunogenicity risk in its Category 2 listing
