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26 These responses may involve oxytocin-mediated vagal afferent signaling and contribute to the central GLP-1 systems role in promoting a negative energy balance
hence, it may have implications on drug elimination rate
In addition to established endocrine mechanisms, such as glucose-dependent insulin secretion, delayed gastric emptying, and appetite suppression, GLP-1 RAs engage in complex bidirectional interactions with the intestinal ecosystem (58)
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doi:10.1080/09513590.2017.1313972 Fruzzetti F, Fidecicchi T, Palla G, Gambacciani M
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