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In the worst-case scenario, introducing contaminated solutions into a sensitive biological system can lead to wildly unpredictable outcomes, from cell culture death to inflammatory responses in in-vivo studies

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Robust human mechanism data are not yet available

But insulin dose reduction needs to be done carefully and gradually, with close CGM monitoring, to avoid either hypoglycemia (from too much insulin relative to your new needs) or hyperglycemia (from reducing too aggressively)