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These data suggest that PGN may alter the absorption of macromolecules by disrupting the intestinal epithelium of the GI tract
The data from Guo et al
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Fuxe K, Strmberg I, Popoli P, Rimondini-Giorgini R, Torvinen M, Ogren SO, et al
In the SURMOUNT-1 trial, participants without diabetes achieved an average body weight reduction of up to about 22.5% after 72 weeks at the highest dose, one of the largest reductions reported for a medication in obesity research
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