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Published preclinical work associates it with collagen and decorin regulation and with broad gene-expression shifts across ECM-related markers
Change in body weight In a post hoc calculation of the substudy cohort ( n = 178), which served to illustrate consistency between weight loss in participants undergoing a DXA scan in the substudy and in the primary study, reduction in total fat plus lean mass was 5.7 kg with semaglutide vs 4.1 kg with canagliflozin in the substudy, suggesting a weight-loss pattern similar to that observed between treatments in the whole SUSTAIN 8 population (Table 2)
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The SURMOUNT-5 trial data you may have seen comparing tirzepatide and semaglutide head-to-head showed tirzepatide outperforming semaglutide at approximately 20.2% vs
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