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Natural growth hormone secretion peaks during deep slow-wave sleep (SWS) stages 3-4, typically 30-90 minutes after sleep onset

Quoting a combination result as though it were the single agent is one of the most common errors in this comparison

A human dose of 200mcg (approximately 2.53mcg/kg for a 70kg adult) does not directly translate to 2.5mcg/kg in a ratpreclinical models use 50100 higher per-kilogram doses to produce comparable GH secretion peaks

Another potential pathophysiological explanation involves the role of the blood-brain barrier

Each capsule contains: This product contains NO milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and sesame