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PDB entry 3pgt captures the enzyme as it is detoxifying a potent carcinogen
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doi:10.1038/nm.3145
The pan-melanocortin non-selectivity, considered a clinical drawback, is precisely a scientific advantage
It belongs to a class of drugs known as multi-receptor agonists, and its mechanism of action is notably broad: it simultaneously activates three hormone receptors the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
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