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Why Rotation Matters When you inject in the same spot repeatedly, several things can happen: Lipohypertrophy: Fatty tissue buildup under the skin that creates lumps or thickened areas Inconsistent absorption: Damaged tissue doesnt absorb medication as predictably, making the drug less effective Skin irritation: Redness, tenderness, or bruising at overused sites Scar tissue formation: Long-term damage to the injection area Simple Rotation Strategies Strategy 1: The Clock Method (for abdomen) Think of your belly as a clock face with your belly button as the center