As of 2023, no GLP-1 transdermal systems have completed Phase 3 clinical trials or received regulatory approval
Spermidine/spermine N1-acetyltransferase 1 (SSAT) initiates polyamine catabolism, which decreases the cellular content of polyamines through transferring the acetyl group of acetyl-CoA to either spermidine or spermine, which can be oxidized by peroxisomal enzyme polyamine oxidase (PAOX)
Most are gastrointestinal and usually mild: Nausea (often improves after 24 weeks) Diarrhea or constipation Bloating or abdominal discomfort Reduced appetite (that one's the point) Fatigue in the first few weeks To minimize them: follow the titration schedule, eat smaller meals, go easy on greasy/high-fat foods, stay hydrated, and consider injecting at bedtime
Your body can't produce it on its own, so you must get it from your diet or through supplementation
And getting it wrong can directly impact how well your medication works over time