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Early studies with broad-spectrum MMP inhibitors, such as batimastat-94, demonstrated improved barrier integrity and reduced hemorrhagic complications by limiting proteolytic TJ degradation in preclinical models of ischemia and inflammation [259]

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GLP-1 (Glucagon-like peptide-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon peptide