A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
The Vitamin D Council a scientist-led group promoting vitamin D deficiency awareness suggests vitamin D treatment might be found helpful in treating or preventing autism, autoimmune disease, cancer, chronic pain, depression, diabetes, heartdisease, high bloodpressure, flu, neuromuscular diseases, and osteoporosis
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NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate [PMID: 16150419] Laboratory literature summary: NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase-cyclohydrolases can rescue mthfd2 null fibroblasts
clinical decisions should involve qualified healthcare providers