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Herder C, Schmitt A, Budden F, Reimer A, Kulzer B, Roden M, et al
Comparative safety evaluation: metformin monotherapy versus combination therapy with GLP-1 receptor agonists The safety analysis incorporated 82,244 adverse event (AE) reports associated with metformin-based therapies
reported that the generation of ROS causes damage to the mitochondria by creating a channel known as the mitochondrial permeability transition pore
These compounds are intended for research use and have not been approved by the FDA for human therapeutic use
Both substances can stress the liver, and together they increase the risk of liver damage
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