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Interestingly, OB GLP-1 signalling is also activated in metabolic stress states, such as obesity and insulin resistance, with an improvement of glucose homeostasis due to increased insulin secretion as shown in our data from obese WD mice
GLP-1 receptor agonists mimic these effects, promoting satiety (feeling full), suppressing glucagon (a blood sugar-raising hormone), and enhancing insulin sensitivity
Diabetes 63 (11), 36373646
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