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Nevertheless, there was some heterogeneity in this observation in the studies with higher baseline age, SBP, use of antihypertensive medications and duration of diabetes (SURPASS-4 and SURPASS-5) where weight loss explained roughly half of the total effect on SBP
Semaglutide discontinuation data from the STEP 1 extension study showed approximately two-thirds of lost weight was regained within one year of stopping treatment
FDA accessdata.fda.gov (2025) 6
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