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GLP-1 + GIP + Glucagon Receptor Activation All benefits of GLP-1 activation (appetite, fullness, insulin) GIP enhances insulin response and may reduce GLP-1 side effects Glucagon increases thermogenesis and energy expenditure Combined effect exceeds sum of individual pathways The idea of using glucagon for weight loss was considered counterintuitive until researchers discovered that glucagons metabolic effects depend heavily on the hormonal context
Other studies, mostly in rodents, found that GLP-1 drugs also change dopamine levels in the brain
Structurally, tirzepatide is engineered to mimic the primary amino acid sequence of GIP while retaining partial agonistic activity at the GLP-1 receptor
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