glp 1 cardioprotective Frontiers Molecular mechanism underlying glucagon‐like peptide‐1

prausnitzii attenuate intestinal fibrosis by inducing macrophage polarization, disrupting mitochondria to inhibit oxidative phosphorylation and glycolysis, and reducing PPAR expression and cholesterol efflux 84

This medication works by mimicking two naturally occurring incretin hormones that regulate blood glucose levels, enhance insulin secretion in response to meals, suppress glucagon release, slow gastric emptying, and reduce appetite

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Nevertheless, the heterogeneity of study designs, sample sizes, and a paucity of long-term safety data highlight the need for standardized protocols and further high-quality trials

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