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Prior to the arrival of GLP1 receptor agonists, weight loss medications had modest impacts on weight loss and were frequently poorly tolerated
Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): A multicentre, randomised, open-label, parallel-group, phase 3 trial
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For example, specific GLP1R variants may correlate with stronger receptor sensitivity in some individuals, while FTO polymorphisms relate to appetite pathway dominance
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