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Semaglutide is one of the most prescribed GLP-1 receptor agonists for weight loss, yet research shows approximately 25% of patients experience minimal weight reduction despite consistent use
Unfortunately, GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), which limits the therapeutic efficacy of native GLP-1 (Deacon et al., 1995)
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METAOD003: A Phase IIa (double-blind, placebo-controlled 4 4 Latin Square design) safety study with single doses (9, 27 and 54 mg AOD9604) administered orally (capsules) to 17 healthy, clinically obese males presenting with a BMI 35 kg/m 2
