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And in the STEP trials, patient-reported physical functioning improved more on the drug than on placebo (STEP patient-reported outcomes, 2024), because unloading forty pounds of fat does more for how a body moves than a modest dip in muscle takes away

[8] [9] Alternative diabetes management strategies should be employed throughout pregnancy and the postnatal period

A 2024 meta-analysis focusing on PCOS patients revealed that GLP-1 receptor agonists significantly lowered fasting insulin levels, improved results on the 2-hour postoral glucose tolerance test, and reduced HOMA-IR, a key marker of insulin resistance

Rather, GLP-1 therapies appear to support the biological environment in which these processes unfold

But the area that we do tend to see the largest amount of muscle loss with is the big muscles in the thighs