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Consequently, ECL1 adopted a more relaxed conformation, making peptide 20 straighter by shifting its tip toward the TMD core by 4.2 (measured by the C of L27 P )
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Clinical trials demonstrate that GLP-1 medications produce 15-22% weight reduction over 68 weeks compared to 2-3% reduction with behavioral intervention alone, representing a 7-10 fold improvement in weight loss efficacy
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