Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEPs mainly included nucleotide excision repair and p53 signaling pathway (Fig
Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)
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Its primary purpose is to neutralize free radicals by offering them an oxygen molecule, thereby protecting cells from damage
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