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On the other hand, major pathological changes in PD include abnormal mitochondrial dysfunction, protein aggregation, oxidative stress, glutamate toxicity, calcium overload, and neuroglial dysfunction
No evidence of severe endocrine, cardiovascular, or hepatic adverse effects has been observed in available research data
Endocrinology 137 , 38913896 (1996)
Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants
The body understands what it needs to function at its best and will leave stores of fat to provide the energy required to sustain the body
