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In line with the well-documented incompatibility between animal experiments and human trials (209, 307, 308), current evidence from systematic reviews identified significant limitations in preclinical animal research, encompassing both the quality of publications and translational value (209, 210)
Conventional L-amino acid peptides are rapidly degraded by proteases (half-life of minutes in biological fluids)
Photoluminescent, upconversion luminescent and nonlinear optical metal-organic frameworks: From fundamental photophysics to potential applications
High-ROS environments can degrade the peptide, which is relevant in oxidative stress model experiments
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