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These patients already had established cardiovascular diseases
Extension study and safety A pre-specified extension period of 104 weeks included 532 participants with a BMI of 35 or more at baseline who completed the main 80-week study and had tolerated their assigned dose of medication
The skin color results from melanin production but excessive melanin creation produces pigmentation that causes skin tone irregularities
Serious adverse events are rare but include pituitary axis suppression with long-term high-dose use and worsening insulin resistance in patients with pre-existing glucose issues
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