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The study did not establish causation, but the event illustrates why small trials cannot be described as proof of safety
The resultant opening of voltage-dependent L-type Ca 2+ channels increases the intracellular concentration of Ca 2+ , which also acts as a second messenger, augmenting neurotransmitter release [33]
It was originally developed to assist individuals with type 2 diabetes in managing their blood sugar levels and continues to be used for this purpose in the UK
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