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Additionally, a portion of TMA may undergo further degradation in the colon, yielding methylamine, dimethylamine (DMA), and ammonia

Clinical adoption should await prospective validation demonstrating improved risk prediction beyond standard parameters (eGFR, albuminuria, HbA1c)

Mapping of PDS5B DNA binding interface and mutant generation We first tested purified PDS5B for the ability to bind fluorescently labeled ssDNA and dsDNA by an electrophoretic mobility shift assay (EMSA) (Fig