Ghrelin induces adiposity in rodents
SGLT2 inhibitors can activate sirtuin 1 (SIRT1)-peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) axis and promote mitochondrial regeneration, [] inhibit reduced nicotinamide adenine nucleotide phosphate (NADPH) oxidase (NOX), reduce reactive oxygen species (ROS) production and improve mitochondrial membrane stability, [] activate Parkin/PTEN-induced putative kinase 1 (PINK1) pathway, clear dysfunctional mitochondria, and maintain cell metabolic homeostasis
2002 Oct;175(1):19-31
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PD has received consulting fees/honoraria from Novo Nordisk, Eli Lilly, Sanofi, AstraZeneca, Boehringer Ingelheim, Mundipharma, Merck Sharp & Dohme, Bayer, Abbott, LVL Medical, and Bastide