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It is noteworthy that the disulfide linkage between homocysteine and the cysteine-rich domain of annexin II is responsible for the homocysteine-specific inhibition of t-PA binding to annexin at the cell surface (Hajjar et al, 1998)
Mevalonate can induce the enrichment of H3K4me3 on the IL-6 and TNF- promoters (141), thereby enhancing the production of inflammatory factors
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it exerts its effects largely through the activation of adenylate cyclase, leading to increased cAMP levels
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