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Permeation across this protective barrier is actively mediated by the organic cation/carnitine transporter known as OCTN2 (SLC22A5)

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International Journal of Molecular Sciences 24 Preprint at (2023)

After further processing, the resulting metabolite is highly polar and rapidly eliminated

These include: Genetics Brain injuries, such as from falls or accidents Medical conditions, such as diabetes or high blood pressure Poor diet Lack of exercise Smoking Toxins Medications or improper use of medications Social isolation and loneliness Reduction in sleep Some of the reasons these factors can reduce brain health are that they increase inflammation in the brain and can also cause a change in the hormone and nutrient levels in the brain (1)