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As of December 2025, GLP-1 RA prescriptions account for more than 7% of all prescriptions
The first is the DPP-4 inhibitors , a separate class of diabetes pills such as sitagliptin (Januvia) and linagliptin (Tradjenta)
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Published mechanistic work describes it acting through the hepatocyte growth factor system rather than at an angiotensin receptor directly, despite being structurally derived from angiotensin IV
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