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In contrast, tirzepatide, a dual GIPR/GLP-1R agonist, has been approved for the treatment of T2DM and additionally produces significant weight loss (Le Roux et al., 2023)

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Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes: heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters