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Tirzepatide also targets visceral fat the fat deep around organs

Diarrhea (30%), vomiting (24%), and constipation (24%) round out the common GI effects

Randomization and interventions Participants will be randomized in a 1:1 ratio using a random number generator to one of two semaglutide discontinuation strategies: (i) immediate cessation, in which participants will continue their current dose for 16 weeks followed by complete discontinuation, or (ii) gradual dose reduction, in which the semaglutide dosage will be reduced by 25% every 4 weeks until complete discontinuation at week 16

Insurers match the prescription indication against the approved use

Researchers should evaluate their results around the four to six week mark to determine whether to continue, adjust, or discontinue their protocol